- Sacha Road
- Safari Road
- Saginaw Parkway
- Saint Andrews Street
- Saint Gregorys Drive
- Salem Place
- Salisbury Avenue
- Saltsman Drive
- Samuelson Street
- Sandalwood Drive
- Sandy Shore Boulevard
- Santa Maria Drive
- Santo Cristo Place
- Savage Drive
- Saxony Circle
- Schlueter Street
- Schofield Street
- Schroeder Drive
- Scott Road
- Scottdale Drive
- Scottfarm Walk
- Scrimger Avenue
- Seaton Road
- Sebas Court
- Sebastian Crescent
- Second Avenue
- Seifert Court
- Sekura Crescent
- Sekura Place
- Sekura Street
- Selkirk Street
- Senior Crescent
- Serviss Street
- Severn Avenue
- Shade Street
- Shadeland Court
- Shadywood Lane
- Shamrock Street
- Shannon Drive
- Shantz Hill
- Shantz Station Road
- Sharpe Avenue
- Shaw Avenue East
- Shaw Avenue West
- Shearson Crescent
- Sheffield Road
- Sheffield Street
- Sheldon Drive
- Shellard Road
- Shepherd Avenue
- Sherring Street
- Sherwood Drive
- Shettleston Drive
- Shingle Bridge Place
- Short Street
- Shouldice Road
- Shouldice Side Road
- Sideroad 10 North
- Sideroad 10 South
- Sideroad 20 South
- Sideroad 25 North
- Sideroad 25 South
- Silver Maple Crescent
- Silverthorne Drive
- Sim Court
- Simcoe Street
- Sinclair Court
- Skipton Crescent
- Small Court
- Smith Road
- Sofron Drive
- South Street
- Southgate Road
- Southview Crescent
- Southwood Drive
- Sparrow Avenue
- Speed Island Trail
- Speedsville Road
- Spiers Crescent
- Spooner Crescent
- Spragues Road
- Spring Street
- Spruce Street
- Stafford Court
- Stager Street
- Stanley Street
- Starr Crescent
- State Street
- Steed Court
- Steeles Crescent
- Stephen Street
- Stewart Avenue
- Stirling Macgregor Drive
- Stock Court
- Stonebrook Road
- Stonecairn Drive
- Stonehaven Place
- Stoneman Court
- Stoneridge Place
- Stonyburn Crescent
- Strathcona Street
- Strome Avenue
- Struck Court
- Studiman Road
- Sugar Maple Court
- Sullivan Court
- Summer Place
- Summerside Crescent
- Summit Avenue
- Suncrest Court
- Sunnyhill Road
- Sunset Boulevard
- Sunset Court
- Swastika Trail
- Sweeney Crescent
- Swift Crescent
- Sylvan Drive